doi: 10.1016/0167-5699(89)90136-9.
Inflammatory and immunomodulatory roles of TGF-beta
- PMID: 2478145
- DOI: 10.1016/0167-5699(89)90136-9
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Inflammatory and immunomodulatory roles of TGF-beta
Immunol Today.
1989 Aug.
Abstract
Transforming growth factors (TGFs) are small polypeptides that were initially defined by their ability to induce transformation of non-neoplastic cells in culture. However, it has become increasingly clear that TGFs are not restricted in function to promoting cell growth. One type of transforming growth factor, TGF-beta, is a multifunctional molecule which has unique and potent effects on many target cells and tissues. In this article, Sharon Wahl, Nancy McCartney-Francis and Stephan Mergenhagen focus on the evolving role of TGF-beta in regulating inflammation, immune responses and tissue repair.
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