The role of vitamin D in skeletal and cardiac muscle function

Abstract

Myopathy is a feature of many inflammatory syndromes. Chronic inflammation has been linked to pathophysiological mechanisms which implicate 1,25 dihydroxyvitamin D3 (1,25-(OH)2D3)-mediated signaling pathways with emerging evidence supporting a role for the vitamin D receptor (VDR) in contractile and metabolic function of both skeletal and cardiac muscle. Altered VDR expression in skeletal and cardiac muscle has been reported to result in significant effects on metabolism, calcium signaling and fibrosis in these tissues. Elevated levels of serum inflammatory cytokines, such as IL-6, TNF-α and IFNγ, have been shown to impact myogenic and nuclear receptor signaling pathways in cancer-induced cachexia. The dysregulation of nuclear receptors, such as VDR and RXRα in muscle cells, has also been postulated to result in myopathy via their effects on muscle structural integrity and metabolism. Future research directions include generating transcriptome-wide information incorporating VDR and its gene targets and using systems biology approaches to identify altered molecular networks in human tissues such as muscle. These approaches will aid in the development of novel therapeutic targeting strategies for inflammation-induced myopathies.

Keywords: cancer cachexia; cardiac muscle and transcriptome; cytokines; skeletal muscle.

Figure 1

VDR as a marker of cardiac dysfunction induced by cancer cachexia. Vitamin D Receptor (VDR) as a molecular marker of maladaptive responses due to cancer cachexia in the heart. VDR has been linked to having cardioprotective mechanisms by maintaining contractile kinetics, and regulating fibrosis and hypertrophy (Yuan et al., ; Tishkoff et al., ; Koleganova et al., 2009).