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Review
. 2014 Apr 9:5:161.
doi: 10.3389/fimmu.2014.00161. eCollection 2014.

Cancer: A Tale of Aberrant PRR Response

Raunaq Singh Nagi  1 , Ashish Shekhar Bhat  1 , Himanshu Kumar  2
Affiliations
Review

Cancer: A Tale of Aberrant PRR Response

Raunaq Singh Nagi et al. Front Immunol. .
No abstract available

Keywords: cancer; inflammation; innate immunity; pattern recognition receptors; regulation.

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Figures

Figure 1
Figure 1
Role of PRRs in maintenance of homeostasis and cancer development. Exposure to any of the various stress stimuli leads to activation of immune system through PRRs (formula image) which results in expansion of a variety of cellular populations and production of numerous cytokines (formula image). A precise sensitive balance at the inflammatory and regulatory front eliminates and reinstates homeostasis within the host. However, under certain circumstances, the precise balance is altered due to aberrant/exaggerated inflammation or failure of regulatory mechanisms to restrict them. Such imbalance results in accumulation of cells and chemicals that deregulate the proliferative pathways; induce angiogenesis and damage the extracellular matrix, thus aiding in origin and/or progression of cancers.
See this image and copyright information in PMC

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