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. 2014 Oct;40(10):1291-8.
doi: 10.1016/j.ejso.2014.03.028. Epub 2014 Apr 12.

VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort

E Lastraioli  1 , L Boni  2 , M R Romoli  1 , S Crescioli  1 , A Taddei  3 , S Beghelli  4 , A Tomezzoli  5 , C Vindigni  6 , L Saragoni  7 , L Messerini  1 , M Bernini  8 , L Bencini  8 , E Giommoni  9 , G Freschi  3 , F Di Costanzo  9 , A Scarpa  4 , P Morgagni  10 , M Farsi  8 , F Roviello  11 , G De Manzoni  12 , P Bechi  3 , A Arcangeli  13 ; Gruppo Italiano di Ricerca Cancro Gastrico (GIRCG)
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VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort

E Lastraioli et al. Eur J Surg Oncol. 2014 Oct.

Abstract

Purpose: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.

Methods: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.

Results: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.

Conclusions: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.

Keywords: Gastric cancer; Immunohistochemistry; Prognostic markers; VEGF-A.

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