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Comment
. 2014 May 1;28(9):926-8.
doi: 10.1101/gad.242420.114.

Dual views of SRF: a genomic exposure

Kathleen A Clark  1 , Barbara J Graves
Affiliations
Comment

Dual views of SRF: a genomic exposure

Kathleen A Clark et al. Genes Dev. .

Abstract

Esnault and colleagues (pp. 943-958) take a genomics approach to investigate the role of SRF (serum response factor) in the serum response of fibroblasts. The well-established dual role of SRF with alternative cofactors and responsiveness to two signaling pathways is illustrated at the genome-wide level, yet new insight comes from this global picture.

Keywords: MRTF; Rho; SRF; TCF; chromatin; signal transduction.

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Figures

Figure 1.
Figure 1.
SRF directs the nuclear response to two signaling pathways via TCFs or MRTFs. (A) Serum activates Rho signaling (which changes actin dynamics) and Ras/MAPK kinase cascade (which phosphorylates TCFs). G-actin binds MRTF directly and modulates its nucleo–cytoplasmic trafficking (Mouilleron et al. 2011). (B) In response to Rho-actin signaling, SRF binding to DNA is stimulated, which involves nucleosome displacement. MRTF’s DNA binding is interdependent with SRF DNA binding (Zaromytidou et al. 2006). In response to Ras/MAPK signaling, prebound SRF functions with TCF, which binds to DNA independently and binds SRF via a dedicated B-box (Mo et al. 2001).
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