Improving the power of GWAS and avoiding confounding from population stratification with PC-Select
- PMID: 24788602
- PMCID: PMC4096359
- DOI: 10.1534/genetics.114.164285
Improving the power of GWAS and avoiding confounding from population stratification with PC-Select
Abstract
Using a reduced subset of SNPs in a linear mixed model can improve power for genome-wide association studies, yet this can result in insufficient correction for population stratification. We propose a hybrid approach using principal components that does not inflate statistics in the presence of population stratification and improves power over standard linear mixed models.
Keywords: GWAS; mixed models; population stratification.
Copyright © 2014 by the Genetics Society of America.
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References
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- Devlin B., Roeder K., 1999. Genomic control for association studies. Biometrics 55(4): 997–1004. - PubMed
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