Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Nov;86(21):8202-6.
doi: 10.1073/pnas.86.21.8202.

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes

V Poli  1 , R Cortese
Affiliations

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes

V Poli et al. Proc Natl Acad Sci U S A. 1989 Nov.

Abstract

Interleukin 6 (IL-6) is responsible for a variety of biological effects related to the activation of defenses against infection or inflammation, including the immune response and the acute-phase reaction. Its mechanism of action is unknown. It has recently been shown to induce transcription of several genes encoding acute-phase proteins. Here we describe the identification of an IL-6 responsive element (IL-6RE) present in the promoter of the human hemopexin gene. This element is necessary and sufficient for the IL-6-dependent activation of transcription. The IL-6 effect does not require de novo protein synthesis. A liver-specific nuclear protein (IL-6DBP) binds to the hemopexin IL-6RE as well as to similar sequences on the promoter of other acute-phase genes. IL-6DBP DNA binding activity is induced by IL-6 via a posttranslational mechanism.

PubMed Disclaimer

References

    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. EMBO J. 1987 May;6(5):1219-24 - PubMed
    1. Mol Cell Biol. 1982 Sep;2(9):1044-51 - PubMed
    1. Cell. 1983 Mar;32(3):725-33 - PubMed
    1. Nucleic Acids Res. 1984 Jul 25;12(14):5589-608 - PubMed

Publication types