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. 2014 Mar 1;15(1):1-5.
doi: 10.5152/jtgga.2014.90197. eCollection 2014.

Role of spiral artery Doppler to screen type 2 endometrial cancer cases

Soner Düzgüner  1 , Mehmet Burak Ozkan  1 , Tuncay Küçüközkan  1 , Enis Ozkaya  1 , Fadıl Kara  1 , Ipek Nur Balın  2 , Vakkas Korkmaz  1 , Mehmet Fatih Karslı  1 , Burak Gültekin  1
Affiliations

Role of spiral artery Doppler to screen type 2 endometrial cancer cases

Soner Düzgüner et al. J Turk Ger Gynecol Assoc. .

Abstract

Objective: The purpose of this study was to determine the value of endometrial blood flow assessment in predicting type 2 endometrial carcinoma.

Material and methods: Sixty-five consecutive post-menopoausal women who had vaginal bleeding were enrolled in the study. All subjects were directed to transvaginal sonography to determine endometrial blood flow and underwent endometrial biopsy. Doppler findings were analysed to predict endometrial pathology. Subjects with unsatisfactory Doppler analyses were excluded from the study.

Results: Mean age of the study population was 50.1±6.9 years (42-73). Mean endometrial thickness was 10.1±2.9 mm (4-15 mm) and mean cancer antigen 125 (CA125) level was 20.1±17.4 U/mL (3-92). Histopathological evaluation revealed 14 cases of type 2 endometrial cancer and 18 cases of endometrial hyperplasia without atypia, while the other 33 cases had normal endometrial tissue. CA125 (Area under curve (AUC)=0.853, p=0.000), spiral artery resistance index (AUC=0.905, p=0.000), and spiral artery peak systolic velocity (AUC=0.822, p=0.000) were significant predictors for the type 2 endometrial cancer cases. Endometrial thickness did not significantly predict pathologic cases (p>0.05). Hyperplasia cases were not predicted by any of these diagnostic modalities (p>0.05).

Conclusion: In patients with postmenopausal bleeding, spiral artery Doppler ultrasound, could play a role in refining the diagnosis of type 2 endometrial carcinoma; however, its predictive value should be evaluated with further studies.

Keywords: Type 2 endometrial cancer; post-menopausal woman; spiral artery Doppler.

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Figures

Figure 1
Figure 1
Algorithm showing the selection of the study population
Figure 2
Figure 2
ROC curve of age, endometrial thickness, spiral artery RI and the PSV to predict endometrial cancer cases
See this image and copyright information in PMC

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