Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014:2014:103068.
doi: 10.1155/2014/103068. Epub 2014 Mar 18.

Involvement of miRNAs in placental alterations mediated by oxidative stress

Alexander Rudov  1 , Walter Balduini  1 , Silvia Carloni  1 , Serafina Perrone  2 , Giuseppe Buonocore  2 , Maria Cristina Albertini  1
Affiliations
Review

Involvement of miRNAs in placental alterations mediated by oxidative stress

Alexander Rudov et al. Oxid Med Cell Longev. 2014.

Abstract

Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, preterm labor, and intrauterine growth restriction. While a considerable number of miRNAs have been related to physiological functions and pathological conditions of the placenta, a direct link among these miRNAs, placental functions, and OS is still lacking. This review summarizes data describing the role of miRNAs in placental pathophysiological processes and their possible impact on OS damaging responses. As miRNAs can be found in circulation, improving our understanding on their role in the pathogenesis of pregnancy related disorders could have an important impact on the diagnosis and prognosis of these diseases.

PubMed Disclaimer

Figures

Figure 1
Figure 1
MicroRNAs modulated by oxidative stress. The microRNAs indicated in the figure are involved in placental development/alterations and in pregnancy related disorders.
See this image and copyright information in PMC

References

    1. Buonocore G, Perrone S, Tataranno ML. Oxygen toxicity: chemistry and biology of reactive oxygen species. Seminars in Fetal and Neonatal Medicine. 2010;15(4):186–190. - PubMed
    1. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology. 2007;39(1):44–84. - PubMed
    1. Dlasková A, Hlavatá L, Ježek P. Oxidative stress caused by blocking of mitochondrial complex I H+ pumping as a link in aging/disease vicious cycle. The International Journal of Biochemistry & Cell Biology. 2008;40:1792–1805. - PubMed
    1. Gupta S, Agarwal A, Banerjee J, Alvarez JG. The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstetrical and Gynecological Survey. 2007;62(5):335–347. - PubMed
    1. Srinivasan T, Sudarsanam D. RNAi: an innate gene Knockdown mechanism. European Journal of Applied Sciences. 2010;2(1):6–9.

Publication types