ADAMTS13, TTP and Beyond

doi:10.4172/2161-1041.1000e104

. 2013;2(1):e104.

doi: 10.4172/2161-1041.1000e104.

ADAMTS13, TTP and Beyond

X Long Zheng¹

Affiliations

Affiliation

¹ Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19194, USA.

PMID: 24790789
PMCID: PMC4001087
DOI: 10.4172/2161-1041.1000e104

ADAMTS13, TTP and Beyond

X Long Zheng. Hereditary Genet. 2013.

. 2013;2(1):e104.

doi: 10.4172/2161-1041.1000e104.

Author

X Long Zheng¹

Affiliation

¹ Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19194, USA.

PMID: 24790789
PMCID: PMC4001087
DOI: 10.4172/2161-1041.1000e104

No abstract available

Keywords: ADAMTS; Atherosclerosis; Inflammation; Thrombosis; Thrombotic thrombocytopenic purpura; Von willebrand factor cleaving protease.

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Conflict of interest statement

Conflict of interest disclosure

Author has no competing financial interests.

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References

1. Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature. 2001;413:488–494. - PubMed
1. Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, et al. Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem. 2001;276:41059–41063. - PubMed
1. Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, et al. Systemic antithrombotic effects of ADAMTS13. J Exp Med. 2006;203:767–776. - PMC - PubMed
1. Xiao J, Jin SY, Xue J, Sorvillo N, Voorberg J, et al. Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis. Arterioscler Thromb Vasc Biol. 2011;31:2261–2269. - PMC - PubMed
1. Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, et al. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood. 2002;100:4033–4039. - PubMed

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P01 HL074124/HL/NHLBI NIH HHS/United States

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[1] Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature. 2001;413:488–494. - PubMed

[2] Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature. 2001;413:488–494. - PubMed

[3] Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, et al. Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem. 2001;276:41059–41063. - PubMed

[4] Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, et al. Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem. 2001;276:41059–41063. - PubMed

[5] Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, et al. Systemic antithrombotic effects of ADAMTS13. J Exp Med. 2006;203:767–776. - PMC - PubMed

[6] Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, et al. Systemic antithrombotic effects of ADAMTS13. J Exp Med. 2006;203:767–776. - PMC - PubMed

[7] Xiao J, Jin SY, Xue J, Sorvillo N, Voorberg J, et al. Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis. Arterioscler Thromb Vasc Biol. 2011;31:2261–2269. - PMC - PubMed

[8] Xiao J, Jin SY, Xue J, Sorvillo N, Voorberg J, et al. Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis. Arterioscler Thromb Vasc Biol. 2011;31:2261–2269. - PMC - PubMed

[9] Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, et al. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood. 2002;100:4033–4039. - PubMed

[10] Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, et al. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood. 2002;100:4033–4039. - PubMed

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ADAMTS13, TTP and Beyond

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ADAMTS13, TTP and Beyond

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