Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr 18;7(2):293-301.
doi: 10.3980/j.issn.2222-3959.2014.02.18. eCollection 2014.

Retinopathy in non diabetics, diabetic retinopathy and oxidative stress: a new phenotype in Central Africa?

Benjamin Longo-Mbenza  1 , Moise Mvitu Muaka  2 , Wayiza Masamba  3 , Lucien Muizila Kini  4 , Igor Longo Phemba  5 , Dalida Kibokela Ndembe  6 , Doris Tulomba Mona  7
Affiliations

Retinopathy in non diabetics, diabetic retinopathy and oxidative stress: a new phenotype in Central Africa?

Benjamin Longo-Mbenza et al. Int J Ophthalmol. .

Abstract

Aim: To evaluate the rates of retinopathy without diabetes and diabetic retinopathy (DR), associated with some markers of oxidative stress, antioxidants and cardiometabolic risk factors.

Methods: We determined the prevalence of DR in 150 type 2 diabetes mellitus (T2DM) patients, that of retinopathy in 50 non diabetics, the levels of body mass index (BMI), waist circumference (WC), blood pressure, lipids, 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), gamma-glutamyl transferase GT (GGT), oxidized low-density lipoprotein (OxLDL), thiobarbituric acid reacting substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), uric acid, creatinine, albumin, total antioxidant status (TAOS), zinc, selenium, magnesium, vitamin C, vitamin D, vitamin E, glucose, apolipoprotein B (ApoB).

Results: The prevalences of DR at 53y and Rtp at 62y were 44% (n=66) and 10% (n=5), respectively. The highest levels of 8-isoprostane, 8-OHdG, TBARS, SOD, and OxLDL were in DR. The lowest levels of vitamin D, vitamin C, TAOS, and vitamin E were in DR. In the case-control study discriminant analysis, the levels of vitamin C, vitamin D, ApoB, 8-OHdG, creatinine, Zn, vitamin E, and WC distinguished significantly non-diabetics without DR (controls), T2DM patients without DR and T2DM patients with DR.

Conclusion: Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2 diabetics. Prevention of oxidative stress and abdominal obesity is needed. Supplementation in vitamin C, D, and E should be recommended as complement therapies of T2DM.

Keywords: Africa; anticipation; apolipoprotein B; diabetic retinopathy; discriminant analysis; oxidative stress.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Discriminant functions for retinopathy presence groups in the case-control study.
Canonical Discriminate Functions case population: case polulation.
Figure 2
Figure 2. Discriminant functions for retinopathy presence groups in all participants.
Canonical discriminate functions.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Yamagishi S, Ueda S, Matsui T, Nakamura K, Okuda S. Role of advanced glycation end products (AGEs) and oxidative stress in diabetic retinopathy. Curr Pharm Des. 2008;14(10):962–968. - PubMed
    1. Chilelli NC, Burlina S, Lapolla A. AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: a “glycoxidation-centric” point of view. Nutr Metab Cardiovasc Dis. 2013;23(10):913–919. - PubMed
    1. Mancino R, Di Pierro D, Varesi C, Cerulli A, Feraco A, Cedrone C, Pinazo-Duran MD, Coletta M, Nucci C. Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy. Mol Vis. 2011;17:1298–1304. - PMC - PubMed
    1. Aldebasi Y, Mohieldein A, Almansour Y, Almoteri B. Imbalance of oxidant/antioxidant status and risk factors for Saudi type 2 diabetic patients with retinopathy. BJMMR. 2011;1(4):371–384.
    1. El-Mesallamy HO, Rizk KA, Hashad IM. Role of oxidative stress, inflammation and endothelial dysfunction in the pathogenesis of diabetic retinopathy. IIOABJ. 2011;2(6):91–97.

LinkOut - more resources