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. 2014 Apr 18;7(2):330-4.
doi: 10.3980/j.issn.2222-3959.2014.02.25. eCollection 2014.

A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG

Curt Hartleben-Matkin  1 , Diddier Prada  2 , Rafael Mancilla-Vences  1
Affiliations

A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG

Curt Hartleben-Matkin et al. Int J Ophthalmol. .

Abstract

Aim: To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma (POAG) and the addition of other intraocular pressure (IOP) lowering medications such as prostaglandin analogs and brimonidine.

Methods: A retrospective, non-randomized, and descriptive clinical study was performed with 182 eyes diagnosed with POAG. Patients were divided into three groups: a group with fixed combination of dorzolamide/timolol only, a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol, and a third group with the addition of brimonidine to the same fixed combination. IOP data were gathered retrospectively and the differences between groups were calculated.

Results: IOP was reduced satisfactorily in all three groups; however, a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin analogs. In this group, a progressive, significant and more homogeneous response of the reduction was noted in comparison with the other groups.

Conclusion: IOP reduction was efficacious in all three groups. The addition of prostaglandin analogs showed progressive IOP reduction, progressive response and absence of long-term drift. Brimonidine did not show a significant additive effect.

Keywords: Cosopt®; brimonidine; dorzolamide/timolol; fixed combination; glaucoma; prostaglandin analogs.

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Figures

Figure 1
Figure 1. Boxplot of baseline IOP in all groups of analysis
A significant statistical difference between groups was find (P=0.023). Cosopt®: 2% dorzolamide/0.5% timolol; Cosopt®+PG: Cosopt®+prostaglandin analogs; Cosopt®+B: Cosopt®+brimonidine. *Outlier data.
Figure 2
Figure 2. Mean IOP at baseline and follow-up in patients with POAG (adjusted)
*: Statistically significant difference between groups.
Figure 3
Figure 3. Percentage of IOP reduction on each group
A: Cosopt®; B: Cosopt®+P; C: Cosopt®+B. Cosopt®: 2% dorzolamide/0.5% timolol; Cosopt®+PG: Cosopt®+prostaglandin analogs; Cosopt®+B: Cosopt ®+brimonidine.
Figure 4
Figure 4. IOP in Cosopt®+PG group at 4y of analysis
Statistical significant differences between periods of treatment are shown. Cosopt®+PG: Cosopt®+prostaglandin analogs. *Outlier data.
See this image and copyright information in PMC

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