[Peculiarities and clinical significance of drug pharmacokinetics and pharmacodynamics during pregnancy]

Abstract

There are relatively few data reported on specific features of drug pharmacokinetics (PK) and pharmacodynamics in pregnancy compared to the non-pregnant state. Changes in maternal physiology and metabolic processes during pregnancy effect on PK and show that standard adult dosing is likely to be incorrect during pregnancy. Physiology-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and to correctly predict drug exposure and response on the personal level.