Export and expression: mRNAs deliver new messages for controlling pluripotency

Arven Saunders¹, Jianlong Wang²

Affiliations

¹ The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jianlong.wang@mssm.edu.

PMID: 24792108
DOI: 10.1016/j.stem.2014.04.009

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Export and expression: mRNAs deliver new messages for controlling pluripotency

Arven Saunders et al. Cell Stem Cell. 2014.

Free article

. 2014 May 1;14(5):549-50.

doi: 10.1016/j.stem.2014.04.009.

Authors

Arven Saunders¹, Jianlong Wang²

Affiliations

¹ The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jianlong.wang@mssm.edu.

PMID: 24792108
DOI: 10.1016/j.stem.2014.04.009

Abstract

Fine-tuning of the pluripotency program is executed by a multitude of cellular processes. Two recent studies published in Cell Stem Cell (Wang et al., 2013; Tahmasebi et al., 2014) provide novel insights into the posttranscriptional and translational regulatory mechanisms controlling stem cell pluripotency and somatic cell reprogramming.

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The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.
Wang L, Miao YL, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward JM, Burkholder A, Lipchina I, Fargo DC, Hochedlinger K, Shi Y, Williams CJ, Hu G. Wang L, et al. Cell Stem Cell. 2013 Dec 5;13(6):676-90. doi: 10.1016/j.stem.2013.10.008. Cell Stem Cell. 2013. PMID: 24315442 Free PMC article.
Multifaceted regulation of somatic cell reprogramming by mRNA translational control.
Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, Kim K, Yang XJ, Sonenberg N. Tahmasebi S, et al. Cell Stem Cell. 2014 May 1;14(5):606-16. doi: 10.1016/j.stem.2014.02.005. Epub 2014 Mar 13. Cell Stem Cell. 2014. PMID: 24630793

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Export and expression: mRNAs deliver new messages for controlling pluripotency

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Export and expression: mRNAs deliver new messages for controlling pluripotency

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