Unresolved questions from the analysis of mice lacking MCU expression

Elizabeth Murphy¹, Xin Pan², Tiffany Nguyen³, Jie Liu², Kira M Holmström², Toren Finkel⁴

Affiliations

¹ Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: murphy1@mail.nih.gov.
² Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
³ Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
⁴ Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: finkelt@nih.gov.

PMID: 24792186
PMCID: PMC4214067
DOI: 10.1016/j.bbrc.2014.04.144

Unresolved questions from the analysis of mice lacking MCU expression

Elizabeth Murphy et al. Biochem Biophys Res Commun. 2014.

. 2014 Jul 11;449(4):384-5.

doi: 10.1016/j.bbrc.2014.04.144. Epub 2014 May 1.

Authors

Elizabeth Murphy¹, Xin Pan², Tiffany Nguyen³, Jie Liu², Kira M Holmström², Toren Finkel⁴

Affiliations

¹ Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: murphy1@mail.nih.gov.
² Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
³ Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
⁴ Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: finkelt@nih.gov.

PMID: 24792186
PMCID: PMC4214067
DOI: 10.1016/j.bbrc.2014.04.144

Abstract

Entry of mitochondrial calcium is believed to play an essential role in regulating bioenergetics and initiating cell death pathways. We have recently described a mouse model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues from these animals do not exhibit any marked protection from cell death. Here, we discuss our findings as well as potential explanations for some of the more unexpected results.

Published by Elsevier Inc.

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References

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1. Yu S, et al. Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A. 1998;95:8715–8720. - PMC - PubMed
1. Feng S, et al. Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake. Proc Natl Acad Sci U S A. 2013;110:11011–11016. - PMC - PubMed

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Unresolved questions from the analysis of mice lacking MCU expression

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Unresolved questions from the analysis of mice lacking MCU expression

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