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. 2014 Aug;18(3):535-43.
doi: 10.1007/s11030-014-9522-x. Epub 2014 May 4.

An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media

Saber Mehrparvar  1 , Saeed Balalaie, Mahnaz Rabbanizadeh, Elmira Ghabraie, Frank Rominger
Affiliations

An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media

Saber Mehrparvar et al. Mol Divers. 2014 Aug.

Abstract

Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum's acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally friendly profile are the advantages of this method for the synthesis of 2-pyridone-3-carboxylic acid derivatives.

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