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. 2014 Jun 5:135:7-16.
doi: 10.1016/j.jphotobiol.2014.04.010. Epub 2014 Apr 24.

Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system

Lin Zhou  1 , Lin Zhou  2 , Shaohua Wei  1 , Xuefeng Ge  1 , Jiahong Zhou  3 , Huijun Jiang  4 , Fuyou Li  5 , Jian Shen  1
Affiliations

Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system

Lin Zhou et al. J Photochem Photobiol B. .

Abstract

Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). However, the anticancer activity of HA was obviously decreased after been loaded on GO. To solve this problem, a chemotherapy drug, 7-ethyl-10-hydroxycamptothecin (SN-38), was co-loaded on the HA loaded GO (HA/SN-38/GO) as a multimodal carrier for the synergistic combination of PDT and chemotherapy for cancer. In vitro results showed that the combination therapy exhibited a synergistic antiproliferative effect compared with PDT and chemotherapy alone. Therefore, HA/SN-38/GO delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer.

Keywords: 7-Ethyl-10-hydroxycamptothecin; Combination therapy; Graphene oxide; Hypocrellin A.

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