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Comparative Study
. 2014 May 2;4(5):e004565.
doi: 10.1136/bmjopen-2013-004565.

Triage tests for identifying atrial fibrillation in primary care: a diagnostic accuracy study comparing single-lead ECG and modified BP monitors

Karen Kearley  1 , Mary Selwood, Ann Van den Bruel, Matthew Thompson, David Mant, Fd Richard Hobbs, David Fitzmaurice, Carl Heneghan
Affiliations
Comparative Study

Triage tests for identifying atrial fibrillation in primary care: a diagnostic accuracy study comparing single-lead ECG and modified BP monitors

Karen Kearley et al. BMJ Open. .

Abstract

Objective: New electronic devices offer an opportunity within routine primary care settings for improving the detection of atrial fibrillation (AF), which is a common cardiac arrhythmia and a modifiable risk factor for stroke. We aimed to assess the performance of a modified blood pressure (BP) monitor and two single-lead ECG devices, as diagnostic triage tests for the detection of AF.

Setting: 6 General Practices in the UK.

Participants: 1000 ambulatory patients aged 75 years and over.

Primary and secondary outcome measures: Comparative diagnostic accuracy of modified BP monitor and single-lead ECG devices, compared to reference standard of 12-lead ECG, independently interpreted by cardiologists.

Results: A total of 79 participants (7.9%) had AF diagnosed by 12-lead ECG. All three devices had a high sensitivity (93.9-98.7%) and are useful for ruling out AF. WatchBP is a better triage test than Omron autoanalysis because it is more specific-89.7% (95% CI 87.5% to 91.6%) compared to 78.3% (95% CI 73.0% to 82.9%), respectively. This would translate into a lower follow-on ECG rate of 17% to rule in/rule out AF compared to 29.7% with the Omron text message in the study population. The overall specificity of single-lead ECGs analysed by a cardiologist was 94.6% for Omron and 90.1% for Merlin.

Conclusions: WatchBP performs better as a triage test for identifying AF in primary care than the single-lead ECG monitors as it does not require expertise for interpretation and its diagnostic performance is comparable to single-lead ECG analysis by cardiologists. It could be used opportunistically to screen elderly patients for undiagnosed AF at regular intervals and/or during BP measurement.

Keywords: Primary Care; Stroke Medicine.

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Figures

Figure 1
Figure 1
Patient recruitment flowchart.
Figure 2
Figure 2
Predictive value of WatchBP and Omron autoanalysis for detecting atrial fibrillation (AF).
Figure 3
Figure 3
Forest plot of diagnostic accuracy per cardiologist of Omron and Merlin single-lead ECGs.
See this image and copyright information in PMC

References

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