Modulation of the cytotoxicity of porfiromycin by dicoumarol in vitro and in vivo
Affiliations
- PMID: 2479329
Item in Clipboard
Modulation of the cytotoxicity of porfiromycin by dicoumarol in vitro and in vivo
Anticancer Res.
1989 Jul-Aug.
Abstract
The effects of dicoumarol (DIC) on the cytotoxicity of porfiromycin (POR) were studied in vitro using EMT6 mammary tumor cells in monolayer cultures and in vivo using solid EMT6 tumors and bone marrow stem cells. In vitro, POR was more toxic to hypoxic EMT6 cells than to aerobic cells. Exposure of aerobic cultures to DIC protected against POR; in contrast, DIC sensitized hypoxic cells to POR. Treatment of mice with DIC produced a slight increase in the toxicity of POR to cells in solid tumors. The toxicity of POR to marrow stem cells (CFU-GM and CFU-MK) was not altered by DIC. Pretreatment of mice with DIC therefore produced a small improvement in the therapeutic ratio.
Similar articles
-
Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.Cancer Res. 1989 Jun 15;49(12):3310-3. Cancer Res. 1989. PMID: 2470504
-
Preclinical studies of porfiromycin as an adjunct to radiotherapy.Radiat Res. 1988 Oct;116(1):100-13. Radiat Res. 1988. PMID: 3186923
-
Correlation between drug uptake and selective toxicity of porfiromycin to hypoxic EMT6 cells.Cancer Res. 1987 Nov 1;47(21):5654-7. Cancer Res. 1987. PMID: 3664473
-
Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro.Cancer Res. 1985 Aug;45(8):3642-5. Cancer Res. 1985. PMID: 3926306
-
Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.Cancer Res. 1985 Jan;45(1):213-6. Cancer Res. 1985. PMID: 2578093
Cited by
-
Cellular pharmacology of quinone bioreductive alkylating agents.Cancer Metastasis Rev. 1993 Jun;12(2):165-76. doi: 10.1007/BF00689808. Cancer Metastasis Rev. 1993. PMID: 8375019 Review.
-
Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.Br J Cancer Suppl. 1996 Jul;27:S9-14. Br J Cancer Suppl. 1996. PMID: 8763837 Free PMC article.