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Case Reports
. 1989 Oct;48(10):856-60.
doi: 10.1136/ard.48.10.856.

Selective removal of anti-double-stranded DNA antibodies by immunoadsorption with dextran sulphate in a patient with systemic lupus erythematosus

M Kinoshita  1 , S Aotsuka, T Funahashi, N Tani, R Yokohari
Affiliations
Case Reports

Selective removal of anti-double-stranded DNA antibodies by immunoadsorption with dextran sulphate in a patient with systemic lupus erythematosus

M Kinoshita et al. Ann Rheum Dis. 1989 Oct.

Abstract

A dextran sulphate gel column removed anti-double-stranded DNA antibodies (anti-dsDNA) selectively, efficiently, and safely from the circulation of a patient with systemic lupus erythematosus (SLE). The mechanism of the removal is thought to be due to cross reactivity of anti-dsDNA with dextran sulphate, which has negatively charged units. Selective removal of anti-dsDNA is expected to contribute not only to the treatment but also to elucidation of the pathogenesis of SLE.

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