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. 2014 Jul;38(7):773-80.
doi: 10.1016/j.leukres.2014.04.001. Epub 2014 Apr 12.

Population-based disparities in survival among patients with core-binding factor acute myeloid leukemia: a SEER database analysis

Andrew M Brunner  1 , Traci M Blonquist  2 , Hossein Sadrzadeh  3 , Ashley M Perry  3 , Eyal C Attar  3 , Philip C Amrein  3 , Karen K Ballen  3 , Yi-Bin Chen  3 , Donna S Neuberg  2 , Amir T Fathi  4
Affiliations

Population-based disparities in survival among patients with core-binding factor acute myeloid leukemia: a SEER database analysis

Andrew M Brunner et al. Leuk Res. 2014 Jul.

Abstract

We performed a retrospective population-based study using the SEER database to assess survival trends in CBF-AML between 2000 and 2010. Median OS increased from 16 months in 2000-2002 to 25 months in 2006-2008 (P=0.002). The 3-year OS rate for patients with inv(16) was 57.3%, but in t(8;21) was only 35.5%. Patients aged 75-84 had worse survival than patients aged 15-44 (HR 5.61, P=0.0002). Black race was associated with higher mortality (HR 1.50, P=0.03). Compared to clinical trial outcomes, CBF-AML survival is poorer in the general population, particularly among African Americans and the elderly, and in t(8;21) compared to inv(16) AML.

Keywords: Acute myeloid leukemia; Core binding factors; Health status disparities; Population surveillance; Survival.

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Figures

Figure 1
Figure 1. Overall survival by period of diagnosis
Overall survival among all patients improved with each successive period of diagnosis (P=0.002). Survival is shown in months.
Figure 2
Figure 2. Overall survival by age of diagnosis among all patients (2A) and of those alive/followed at 1 month (2B)
Patient age was significantly associated with overall survival among all patients with CBF-AML. Patient survival decreased with increasing age both at diagnosis (2A, P<0.0001) and among the subset of patients who were alive and followed after 1 month (2B, P<0.0001).
Figure 2
Figure 2. Overall survival by age of diagnosis among all patients (2A) and of those alive/followed at 1 month (2B)
Patient age was significantly associated with overall survival among all patients with CBF-AML. Patient survival decreased with increasing age both at diagnosis (2A, P<0.0001) and among the subset of patients who were alive and followed after 1 month (2B, P<0.0001).
Figure 3
Figure 3. Overall survival by race/ethnicity
There was a significant association between patient race/ethnicity and survival among all patients with CBF-AML (P=0.003). Black patients had poorer overall survival compared to white non-Hispanic patients.
Figure 4
Figure 4. Overall Survival by CBF-AML type
There were differences in overall survival by CBF-AML cytogenetic subtype. Patients with t(8;21) CBF-AML had significantly worse survival compared to those with inv(16) CBF-AML.
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