[Locomotive syndrome]

Abstract

Both cognitive impairment (CI) and osteoarthritis (OA) are top-ranked causes of disability requiring support, but there have been no previous reports on the association between CI and OA. We aimed to investigate the association between mild cognitive impairment (MCI) and the occurrence and progression of OA of the knee among men and women who participated in the research on osteoarthritis/osteoporosis against disability (ROAD) study. Of 1,690 participants at the baseline, 1,384 individuals (81.9%; 466 men, 918 women) completed the second survey including knee radiography 3 years later. Baseline presence of MCI was significantly associated with the incidence of knee OA (vs. non-occurrence of knee OA; OR 4.90, p < 0.05).