Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 May 6:20:742-6.
doi: 10.12659/MSM.890158.

Division of the stapedial tendon results in noise-induced damage to the inner ear

Ramazan Ocalan  1 , Fatma Ceyda Akin  1 , Yavuz Fuat Yilmaz  2 , Samet Ozlugedik  2 , Seren Gulsen Gurgen  3
Affiliations

Division of the stapedial tendon results in noise-induced damage to the inner ear

Ramazan Ocalan et al. Med Sci Monit. .

Abstract

Background: The effect of division of the stapedial tendon on susceptibility to noise-induced inner ear damage has not been previously studied. This study aimed to evaluate the effects of noise exposure following division of the stapedial tendon in guinea pigs.

Material and methods: Ten adult albino guinea pigs were used. The stapedial tendon of each right ear was cut. The stapedial tendon in each left ear was left intact and these ears served as a control group. DPOAEs and ABR tests were performed before and 10 days after noise exposure. The animals were exposed to a 110-dB noise stimulus for 6 h in a silent room a week after surgery. Cochleas of the animals were removed, and inner and outer hair cells were examined under a light microscope.

Results: We found that noise exposure adversely affected DPOAE measurements at all frequencies except 2 KHz in experimental ears. Noise exposure also produced significantly elevated ABR thresholds in experimental ears at 2, 4, 8, and 16 KHz. On histopathological examination, we found a significantly greater prevalence of apoptotic cells in the experimental ears.

Conclusions: Based on these findings, we can conclude that after division of the stapedial tendon, noise exposure may cause damage to the inner ear. This is the first study in the English literature that demonstrates the potential protective effect of the stapedial tendon against acoustic damage.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean DPOAE amplitudes in control and experimental groups before and after noise exposure.
Figure 2
Figure 2
(A) Control group spiral ligament and outer hair cells. SLig: Spiral ligament, BM: Basilar membrane, → : Outer hair cells. TUNEL staining 400× (OM). (B) Experimental group spiral ligaments and outer hair cells. SLig: Spiral ligament, BM: Basilar membrane, →: Outer hair cells. TUNEL staining 400× (OM).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Sendowski I, Raffin F, Braillon-Cros A. Therapeutic efficacy of magnesium after acoustic trauma caused by gunshot noise in guinea pigs. Acta Otolaryngol. 2006;126(2):122–29. - PubMed
    1. Linss W, Linss V, Emmerich E, Richter F. Scanning electron microscopic findings concerning the formation of the organ of corti near the helicotrema in guinea pigs. Ann Anat. 2000;182(5):445–49. - PubMed
    1. Neely ST, Kim DO. An active cochlear model showing sharp tuning and high sensitivity. Hear Res. 1983;9(2):123–30. - PubMed
    1. Avan P, Bonfils P, Loth D, Wit HP. Temporal patterns of transient-evoked otoacoustic emissions in normal and impaired cochlea. Hear Res. 1993;1(70):109–20. - PubMed
    1. Taniguchi M, Hakuba N, Koga K, et al. Apoptotic hair cell death after transient cochlear ischemia in gerbils. Neuroreport. 2002;13(18):2459–62. - PubMed