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Review
. 2014 Jun;21(3):486-95.
doi: 10.1007/s12350-014-9902-8. Epub 2014 May 6.

Endocarditis and molecular imaging

Peter Panizzi  1 , James R Stone, Matthias Nahrendorf
Affiliations
Review

Endocarditis and molecular imaging

Peter Panizzi et al. J Nucl Cardiol. 2014 Jun.
No abstract available

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Figures

Figure 1
Figure 1. Clinical Case of Recurrent Gram-positive Endocarditis
A. Hematoxylin and eosin (H&E) stained histologic section showing fibrin vegetation (top) on the mitral valve (bottom), 100× magnification. B. Tissue Gram stain showing Gram positive cocci (arrowheads) in the vegetation, 2000× magnification.
Figure 2
Figure 2. Pathogenesis of S. aureus Endocarditis
Initially, valve damage causes a small clot to form on the denuded endothelium. Next, circulating new bacteria (highlighted in red) attach, and prothrombin activators are secreted to elicit layered fibrin deposition (modified from Korzeniowski et al. (65)).
Figure 3
Figure 3. Bioluminescence Imaging in a Mouse Model of Endocarditis
A. Induction involves catheter insertion followed by intravenous injection of bacteria. B. Bioluminescence imaging after infection with the S. aureus strain Xen 29. C. H&E stain of vegetation in aortic root. D. Gram stain of an adjacent section. Modified from Panizzi et al. (27)).
Figure 4
Figure 4. Imaging of Endocarditis with an Agent Targeted to S. aureus Produced Staphylocoagulase
Left panels show a fluorochrome prothrombin analogon for optical imaging, right panels a 64-copper labeled PET version of the reporter. The arrow points out the suture in the left ventricular outflow tract (asterisk). Modified from Panizzi et al. (27).
Figure 5
Figure 5. Clinical 18FDG PET/CT Imaging
PET/CT in a patient with a definite diagnosis of prosthetic valve endocarditis. The high uptake (yellow arrows) is observed at the level of the anterior aortic annulus. From Saby et al. (63).
See this image and copyright information in PMC

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