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. 2014 Aug 1;66(4):452-6.
doi: 10.1097/QAI.0000000000000187.

A prospective cohort study of the effect of depot medroxyprogesterone acetate on detection of plasma and cervical HIV-1 in women initiating and continuing antiretroviral therapy

Summer Day  1 , Susan M Graham, Linnet N Masese, Barbra A Richardson, James N Kiarie, Walter Jaoko, Kishorchandra Mandaliya, Vrasha Chohan, Julie Overbaugh, R Scott McClelland
Affiliations

A prospective cohort study of the effect of depot medroxyprogesterone acetate on detection of plasma and cervical HIV-1 in women initiating and continuing antiretroviral therapy

Summer Day et al. J Acquir Immune Defic Syndr. .

Abstract

Depot medroxyprogesterone acetate (DMPA) use among HIV-1-infected women may increase transmission by increasing plasma and genital HIV-1 RNA shedding. We investigated associations between DMPA use and HIV-1 RNA in plasma and cervical secretions. One hundred two women initiated antiretroviral therapy, contributing 925 follow-up visits over a median of 34 months. Compared with visits with no hormonal contraception exposure, DMPA exposure did not increase detection of plasma (adjusted odds ratio: 0.81, 95% confidence interval: 0.47 to 1.39) or cervical HIV-1 RNA (adjusted odds ratio: 1.41, 95% confidence interval: 0.54 to 3.67). Our results suggest that DMPA is unlikely to increase infectivity in HIV-positive women who are adherent to effective antiretroviral therapy.

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Conflict of interest statement

Conflicts of Interest: All other authors reported no conflicts of interest.

Figures

Figure 1
Figure 1
Plasma HIV-1 RNA (PVL) and cervical HIV-1 RNA (CVL) in 102 women throughout 36 months of follow-up on ART in Mombasa, Kenya. *Among women with detectable HIV-1 RNA
See this image and copyright information in PMC

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