Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 May 2;12(5):2539-89.
doi: 10.3390/md12052539.

Bioactive marine drugs and marine biomaterials for brain diseases

Clara Grosso  1 , Patrícia Valentão  2 , Federico Ferreres  3 , Paula B Andrade  4
Affiliations

Bioactive marine drugs and marine biomaterials for brain diseases

Clara Grosso et al. Mar Drugs. .

Abstract

Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development. This review aims to summarize the potential of drugs derived from marine invertebrates in the field of neuroscience. Therefore, some examples of neuroprotective drugs and neurotoxins will be discussed. Their role in neuroscience research and development of new therapies targeting the central nervous system will be addressed, with particular focus on neuroinflammation and neurodegeneration. In addition, the neuronal growth promoted by marine drugs, as well as the recent advances in neural tissue engineering, will be highlighted.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Potent marine drugs affecting neuronal growth and synaptic functions.
Figure 2
Figure 2
AChE and BACE1 inhibitors isolated from marine invertebrates.
Figure 3
Figure 3
Most potent protein kinases inhibitors from marine organisms.
Figure 4
Figure 4
Potent marine modulators of voltage-dependent and ligand-gated ion channels.
Figure 5
Figure 5
Marine compounds with protective effects against Aβ, 6-OHDA, MPP+ and IAA.
Figure 6
Figure 6
Anti-neuroinflammatory marine compounds.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kanwar J.R., Sriramoju B., Kanwar R.K. Neurological disorders and therapeutics targeted to surmount the blood-brain barrier. Int. J. Nanomedicine. 2012;7:3259–3278. - PMC - PubMed
    1. Glaser K.B., Mayer A.M.S. A renaissance in marine pharmacology: From preclinical curiosity to clinical reality. Biochem. Pharmacol. 2009;78:440–448. doi: 10.1016/j.bcp.2009.04.015. - DOI - PubMed
    1. Mayer A.M.S., Rodríguez A.D., Berlinck R.G.S., Fusetani N. Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. 2011;153:191–222. doi: 10.1016/j.cbpc.2010.08.008. - DOI - PMC - PubMed
    1. Essack M., Bajic V.B., Archer J.A.C. Conotoxins that confer therapeutic possibilities. Mar. Drugs. 2012;10:1244–1265. doi: 10.3390/md10061244. - DOI - PMC - PubMed
    1. Mortari M.R., Cunha A.O.S., Ferreira L.B., dos Santos W.F. Neurotoxins from invertebrates as anticonvulsants: From basic research to therapeutic application. Pharmacol. Ther. 2007;114:171–183. doi: 10.1016/j.pharmthera.2007.01.009. - DOI - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources