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. 2014 May 2;12(5):2539-89.
doi: 10.3390/md12052539.

Bioactive marine drugs and marine biomaterials for brain diseases

Clara Grosso  1 , Patrícia Valentão  2 , Federico Ferreres  3 , Paula B Andrade  4
Affiliations

Bioactive marine drugs and marine biomaterials for brain diseases

Clara Grosso et al. Mar Drugs. .

Abstract

Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development. This review aims to summarize the potential of drugs derived from marine invertebrates in the field of neuroscience. Therefore, some examples of neuroprotective drugs and neurotoxins will be discussed. Their role in neuroscience research and development of new therapies targeting the central nervous system will be addressed, with particular focus on neuroinflammation and neurodegeneration. In addition, the neuronal growth promoted by marine drugs, as well as the recent advances in neural tissue engineering, will be highlighted.

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Figures

Figure 1
Figure 1
Potent marine drugs affecting neuronal growth and synaptic functions.
Figure 2
Figure 2
AChE and BACE1 inhibitors isolated from marine invertebrates.
Figure 3
Figure 3
Most potent protein kinases inhibitors from marine organisms.
Figure 4
Figure 4
Potent marine modulators of voltage-dependent and ligand-gated ion channels.
Figure 5
Figure 5
Marine compounds with protective effects against Aβ, 6-OHDA, MPP+ and IAA.
Figure 6
Figure 6
Anti-neuroinflammatory marine compounds.
See this image and copyright information in PMC

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