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. 1989 Nov 11;17(21):8569-80.
doi: 10.1093/nar/17.21.8569.

RNA-binding properties of influenza A virus matrix protein M1

L Wakefield  1 , G G Brownlee
Affiliations
Free PMC article

RNA-binding properties of influenza A virus matrix protein M1

L Wakefield et al. Nucleic Acids Res. .
Free PMC article

Abstract

The matrix protein (M1) of influenza A virus, which has a critical role in viral assembly and can inhibit the viral transcriptase complex, has the ability to bind RNA. The RNA-binding property of M1 is specific for single-stranded RNA, like that of influenza nucleoprotein (NP) and shows similar sensitivity to pH and to salt concentration. M1:RNA complexes are stable, once formed, to competition from excess single-stranded RNA. The possible location of the RNA-binding regions in the M1 protein is discussed.

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References

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