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. 2014 Jan;12(1):1-6.

Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization/ intracytoplasmic sperm injection: A randomized clinical trial

Afsoon Zarei  1 , Mohammad Ebrahim Parsanezhad  2 , Masoumeh Younesi  3 , Saeed Alborzi  1 , Jaleh Zolghadri  1 , Alamtaj Samsami  1 , Sedigheh Amooee  1 , Shahintaj Aramesh  1
Affiliations

Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization/ intracytoplasmic sperm injection: A randomized clinical trial

Afsoon Zarei et al. Iran J Reprod Med. 2014 Jan.

Abstract

Background: The direct effect of hCG on the human endometrium was studied several times.

Objective: The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET).

Materials and methods: In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250μg intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and pregnancy rates were compared between groups.

Results: Patients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical pregnancy rates (34.5% vs. 20.4%; p=0.044) and ongoing pregnancy rate (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic pregnancy rates (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively.

Conclusion: Intrauterine injection of 250μg of rhCG before ET significantly improves the implantation and pregnancy rates in IVF/ICSI cycles.

Registration id in irct: IRCT2012121711790N1 This article extracted from fellowship course thesis. (Masoumeh Younesi).

Keywords: Implantation rate; In vitro fertilization (IVF); Intracytoplasmic sperm injection (ICSI); Pregnancy rate; Recombinant human chorionic gonadotropin (rhCG).

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