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Review
. 2014:2014:906965.
doi: 10.1155/2014/906965. Epub 2014 Apr 1.

Global consequences of liver ischemia/reperfusion injury

Constantinos Nastos  1 , Konstantinos Kalimeris  2 , Nikolaos Papoutsidakis  2 , Marios-Konstantinos Tasoulis  1 , Panagis M Lykoudis  3 , Kassiani Theodoraki  4 , Despoina Nastou  5 , Vassilios Smyrniotis  5 , Nikolaos Arkadopoulos  5
Affiliations
Review

Global consequences of liver ischemia/reperfusion injury

Constantinos Nastos et al. Oxid Med Cell Longev. 2014.

Abstract

Liver ischemia/reperfusion injury has been extensively studied during the last decades and has been implicated in the pathophysiology of many clinical entities following hepatic surgery and transplantation. Apart from its pivotal role in the pathogenesis of the organ's post reperfusion injury, it has also been proposed as an underlying mechanism responsible for the dysfunction and injury of other organs as well. It seems that liver ischemia and reperfusion represent an event with "global" consequences that influence the function of many remote organs including the lung, kidney, intestine, pancreas, adrenals, and myocardium among others. The molecular and clinical manifestation of these remote organs injury may lead to the multiple organ dysfunction syndrome, frequently encountered in these patients. Remote organ injury seems to be in part the result of the oxidative burst and the inflammatory response following reperfusion. The present paper aims to review the existing literature regarding the proposed mechanisms of remote organ injury after liver ischemia and reperfusion.

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Figures

Figure 1
Figure 1
Distant organs that have been implicated in the remote injury after hepatic ischemia/reperfusion.
Figure 2
Figure 2
Mechanisms involved in remote injury to the kidney after liver ischemia/reperfusion.
Figure 3
Figure 3
Mechanisms involved in remote injury to the gut mucosa leading to gut barrier failure after liver ischemia/reperfusion.
See this image and copyright information in PMC

References

    1. Douzinas EE, Livaditi O, Tasoulis M-K, et al. Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation. PLoS ONE. 2012;7(3)e32968 - PMC - PubMed
    1. Arkadopoulos N, Defterevos G, Nastos C, et al. Development of a porcine model of post-hepatectomy liver failure. Journal of Surgical Research. 2011;170(2):e233–e242. - PubMed
    1. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. American Journal of Physiology—Gastrointestinal and Liver Physiology. 2003;284(1):G15–G26. - PubMed
    1. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. American Journal of Surgery. 2001;181(2):160–166. - PubMed
    1. Chen Y, Xie X. Tacrolimus attenuates myocardium damage to the total hepatic ischemia-reperfusion via regulation of the mitochondrial function. Journal of Surgical Research. 2012;172(1):e47–e54. - PubMed

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