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. 2014 Jan 1;3(1):e27456.
doi: 10.4161/onci.27456. Epub 2014 Jan 3.

The immune landscape of human tumors: Implications for cancer immunotherapy

Gabriela Bindea  1 , Bernhard Mlecnik  1 , Helen K Angell  2 , Jérôme Galon  1
Affiliations

The immune landscape of human tumors: Implications for cancer immunotherapy

Gabriela Bindea et al. Oncoimmunology. .

Abstract

Understanding the spontaneous immune response of cancer patients is critical for the design of efficient anticancer immunotherapies. The power of integrative tumor immunology approaches allowed for a comprehensive view of the immune system evolution in the course of tumor progression and recurrence. We have demonstrated that tumor-infiltrating immune cells are spatiotemporally regulated, a finding that has profound implications for the development of efficient anticancer immunotherapies.

Keywords: bioinformatics; cancer; immune landscape; immunoscore; prognosis.

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Figures

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Figure 1. Immune contexture and mechanisms associated with patient’s prolonged survival. Schematic representation of tumors and major immune cells associated with the proper immune contexture. The tertiary lymphoid structure, TFH and B cell axis, through the production of CXCL13 and IL21 shapes with the chemokines CXCL9, CXCL10, CXCL11, CCL5, and CCL2, the memory, Th1 and cytotoxic T cell response.
See this image and copyright information in PMC

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