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. 2014 Aug;122(8):837-42.
doi: 10.1289/ehp.1307568. Epub 2014 May 6.

Associations of fine particulate matter species with mortality in the United States: a multicity time-series analysis

Lingzhen Dai  1 , Antonella Zanobetti, Petros Koutrakis, Joel D Schwartz
Affiliations

Associations of fine particulate matter species with mortality in the United States: a multicity time-series analysis

Lingzhen Dai et al. Environ Health Perspect. 2014 Aug.

Erratum in

Abstract

Background: Epidemiological studies have examined the association between PM2.5 and mortality, but uncertainty remains about the seasonal variations in PM2.5-related effects and the relative importance of species.

Objectives: We estimated the effects of PM2.5 species on mortality and how infiltration rates may modify the association.

Methods: Using city-season specific Poisson regression, we estimated PM2.5 effects on approximately 4.5 million deaths for all causes, cardiovascular disease (CVD), myocardial infarction (MI), stroke, and respiratory diseases in 75 U.S. cities for 2000-2006. We added interaction terms between PM2.5 and monthly average species-to-PM2.5 proportions of individual species to determine the relative toxicity of each species. We combined results across cities using multivariate meta-regression, and controlled for infiltration.

Results: We estimated a 1.18% (95% CI: 0.93, 1.44%) increase in all-cause mortality, a 1.03% (95% CI: 0.65, 1.41%) increase in CVD, a 1.22% (95% CI: 0.62, 1.82%) increase in MI, a 1.76% (95% CI: 1.01, 2.52%) increase in stroke, and a 1.71% (95% CI: 1.06, 2.35%) increase in respiratory deaths in association with a 10-μg/m3 increase in 2-day averaged PM2.5 concentration. The associations were largest in the spring. Silicon, calcium, and sulfur were associated with more all-cause mortality, whereas sulfur was related to more respiratory deaths. County-level smoking and alcohol were associated with larger estimated PM2.5 effects.

Conclusions: Our study showed an increased risk of mortality associated with PM2.5, which varied with seasons and species. The results suggest that mass alone might not be sufficient to evaluate the health effects of particles.

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Conflict of interest statement

The authors declare they have no actual or potential competing financial interests.

Figures

Figure 1
Figure 1
Spatial variations in estimated PM2.5 effects between cities.
Figure 2
Figure 2
Estimated percent difference in mortality for a 10-μg/m3 increase in PM2.5 at lag 0–1 and an increase of 10th or 90th percentile of distribution of monthly species-to-PM2.5 proportions, controlled for city–season specific temperature. *p ≤ 0.1 for the interaction term. **p ≤ 0.05 for the interaction term.
Figure 3
Figure 3
Relationship between estimated effects of PM2.5 on all-cause mortality and temperature (controlled for smoking and alcohol consumption).
See this image and copyright information in PMC

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