Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:541709.
doi: 10.1155/2014/541709. Epub 2014 Apr 2.

Assessment of lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1, interleukin-6, homocysteine, and uric acid levels in patients with psoriasis

Arzu Ataseven  1 , Recep Kesli  2 , Gulcan Saylam Kurtipek  1 , Perihan Ozturk  3
Affiliations

Assessment of lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1, interleukin-6, homocysteine, and uric acid levels in patients with psoriasis

Arzu Ataseven et al. Dis Markers. 2014.

Abstract

Background: Chronic inflammation may play a role in psoriasis pathogenesis. Lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1 (sTNFR-1), interleukin-6, homocysteine, and uric acid are inflammatory and/or biochemical markers. However, both the roles of these markers and the pathogenesis of psoriasis are unknown.

Objective: The aim of this study was to investigate serum levels of lipocalin 2, clusterin, sTNFR-1, interleukin-6, homocysteine, and uric acid in patients and controls groups.

Methods: Fifty-six patients with psoriasis and 33 healthy controls were included in the study. Serum concentrations of the markers were evaluated by ELISA. The Psoriasis Area and Severity Index (PASI) was evaluated in all psoriasis patients. Body mass index (BMI) was calculated by dividing weight (kg) by height (m) squared.

Results: The serum value of lipocalin and sTNFR-1 were significantly higher in psoriasis patients than in controls (resp., P < 0.001, P < 0.05). The others showed no significant differences between psoriasis and the control groups (all of them P > 0.05). The mean PASI score in the patient group was 8.3 ± 6.5.

Conclusions: These findings suggest that lipocalin 2 and sTNFR-1 might play a role in the pathogenesis of psoriasis and can be used as markers of the disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Lipocalin 2 levels in psoriasis and control groups.
Figure 2
Figure 2
sTNFR-1 levels in psoriasis and control groups.
Figure 3
Figure 3
Positive correlation of uric acid levels and PASI.
Figure 4
Figure 4
Positive correlation of homocysteine levels and PASI.
Figure 5
Figure 5
Positive correlation of IL-6 levels and BMI.
Figure 6
Figure 6
Positive correlation of uric acid levels and BMI.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ceyhan AM, Yildirim M, Ceyhan BM, Sütçü R. Serum neopterin and TNF-α levels in psoriasis and their correlation with disease severity. Turkderm Deri Hastaliklari ve Frengi Arsivi. 2012;46(1):7–10.
    1. Kamata M, Tada Y, Tatsuta A, et al. Serum lipocalin-2 levels are increased in patients with psoriasis. Clinical and Experimental Dermatology. 2012;37(3):296–299. - PubMed
    1. Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432(7019):917–921. - PubMed
    1. Cowland JB, Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics. 1997;45(1):17–23. - PubMed
    1. Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochimica et Biophysica Acta. 2012;1826(1):129–169. - PMC - PubMed