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. 2014:2014:541709.
doi: 10.1155/2014/541709. Epub 2014 Apr 2.

Assessment of lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1, interleukin-6, homocysteine, and uric acid levels in patients with psoriasis

Arzu Ataseven  1 , Recep Kesli  2 , Gulcan Saylam Kurtipek  1 , Perihan Ozturk  3
Affiliations

Assessment of lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1, interleukin-6, homocysteine, and uric acid levels in patients with psoriasis

Arzu Ataseven et al. Dis Markers. 2014.

Abstract

Background: Chronic inflammation may play a role in psoriasis pathogenesis. Lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1 (sTNFR-1), interleukin-6, homocysteine, and uric acid are inflammatory and/or biochemical markers. However, both the roles of these markers and the pathogenesis of psoriasis are unknown.

Objective: The aim of this study was to investigate serum levels of lipocalin 2, clusterin, sTNFR-1, interleukin-6, homocysteine, and uric acid in patients and controls groups.

Methods: Fifty-six patients with psoriasis and 33 healthy controls were included in the study. Serum concentrations of the markers were evaluated by ELISA. The Psoriasis Area and Severity Index (PASI) was evaluated in all psoriasis patients. Body mass index (BMI) was calculated by dividing weight (kg) by height (m) squared.

Results: The serum value of lipocalin and sTNFR-1 were significantly higher in psoriasis patients than in controls (resp., P < 0.001, P < 0.05). The others showed no significant differences between psoriasis and the control groups (all of them P > 0.05). The mean PASI score in the patient group was 8.3 ± 6.5.

Conclusions: These findings suggest that lipocalin 2 and sTNFR-1 might play a role in the pathogenesis of psoriasis and can be used as markers of the disease.

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Figures

Figure 1
Figure 1
Lipocalin 2 levels in psoriasis and control groups.
Figure 2
Figure 2
sTNFR-1 levels in psoriasis and control groups.
Figure 3
Figure 3
Positive correlation of uric acid levels and PASI.
Figure 4
Figure 4
Positive correlation of homocysteine levels and PASI.
Figure 5
Figure 5
Positive correlation of IL-6 levels and BMI.
Figure 6
Figure 6
Positive correlation of uric acid levels and BMI.
See this image and copyright information in PMC

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