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Review
. 2014 May 7;20(17):5119-23.
doi: 10.3748/wjg.v20.i17.5119.

Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis

Xi-Qing Ji  1 , Jun-Feng Du  1 , Gang Chen  1 , Guang Chen  1 , Bo Yu  1
Affiliations
Review

Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis

Xi-Qing Ji et al. World J Gastroenterol. .

Abstract

Aim: To compare the efficacy and tolerance of ilaprazole compared with other proton pump inhibitors (PPIs) in the treatment of duodenal ulcer.

Methods: An electronic database search of Medline, Embase, the Cochrane controlled trials register, Web of Science, PubMed, and the Chinese Biomedical Literature Database (updated to July 2013), and manual searches were conducted. A meta-analysis of randomized controlled trials comparing the efficacy and tolerance of ilaprazole and other PPIs in the treatment of duodenal ulcers was performed.

Results: Five articles involving 1481 patients were included. The meta-analysis showed no difference in the 4-wk healing rate between ilaprazole and other PPIs [89.7% vs 87.0%; relative risk (RR) = 1.02; 95%CI: 0.98-1.06; Z = 1.00; P = 0.32]. The results did not change in the sensitivity analyses. The meta-analysis indicated that the adverse effect rate in the ilaprazole group was lower than that in the control group, but the difference was not significant (9.7% vs 13.0%; RR = 0.81; 95%CI: 0.60-1.07; Z = 1.47; P = 0.14).

Conclusion: Ilaprazole is a highly effective and safe PPI in the treatment of duodenal ulcers. Ilaprazole can be recommended as a therapy for acid-related disorders, especially in Asian populations.

Keywords: Duodenal ulcer; Ilaprazole; Meta-analysis; Proton pump inhibitor.

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Figures

Figure 1
Figure 1
Meta-analysis chart. A: Meta-analysis of 4-wk healing rate comparing ilaprazole at 10 mg/d with other proton pump inhibitors (PPIs); B: Meta-analysis of adverse effects comparing 10 mg/d ilaprazole with other PPIs.
Figure 2
Figure 2
Funnel plot of the included trials comparing 10 mg/d ilaprazole with other proton pump inhibitors.
See this image and copyright information in PMC

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