Antioxidant strategies and respiratory disease of the preterm newborn: an update
- PMID: 24803984
- PMCID: PMC3996983
- DOI: 10.1155/2014/721043
Antioxidant strategies and respiratory disease of the preterm newborn: an update
Abstract
Preterm newborns are challenged by an excessive oxidative burden, as a result of several perinatal stimuli, as intrauterine infections, resuscitation, mechanical ventilation, and postnatal complications, in the presence of immature antioxidant capacities. "Oxygen radical disease of neonatology" comprises a wide range of conditions sharing a common pathway of pathogenesis and includes bronchopulmonary dysplasia (BPD) and other main complications of prematurity. Antioxidant strategies may be beneficial in the prevention and treatment of oxidative stress- (OS-) related lung disease of the preterm newborn. Endotracheal supplementation or lung-targeted overexpression of superoxide dismutase was proved to reduce lung damage in several models; however, the supplementation in preterm newborn failed to reduce the risk of BPD, although long-term respiratory outcomes were improved. Also melatonin administration to small cohorts of preterm newborns suggested beneficial effects on lung OS. The possibility to identify single nucleotide polymorphism affecting the risk of BPD may help to identify specific populations with particularly high risk of OS-related diseases and may pose the basis for individually targeted treatments. Finally, surfactant replacement may lead to local anti-inflammatory and antioxidant effects, thanks to specific enzymatic and nonenzymatic antioxidants naturally present in animal surfactants.
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References
-
- Saugstad OD. Oxidative stress in the newborn-a 30-year perspective. Biology of the Neonate. 2005;88(3):228–236. - PubMed
-
- Buonocore G, Perrone S, Tataranno ML. Oxygen toxicity: chemistry and biology of reactive oxygen species. Seminars in Fetal and Neonatal Medicine. 2010;15(4):186–190. - PubMed
-
- Kinsella JP, Greenough A, Abman SH. Bronchopulmonary dysplasia. The Lancet. 2006;367(9520):1421–1431. - PubMed
-
- Perrone S, Tataranno ML, Negro S, et al. Early identification of the risk for free radical-related diseases in preterm newborns. Early Human Development. 2010;86(4):241–244. - PubMed
-
- Perrone S, Negro S, Tataranno ML, Buonocore G. Oxidative stress and antioxidant strategies in newborns. Journal of Maternal-Fetal and Neonatal Medicine. 2010;23(3):63–65. - PubMed
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