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. 2014 Spring;3(1):9-16.

Focal laser photocoagulation in non-center involved diabetic macular edema

Irfan Perente  1 , Zeynep Alkin  1 , Abdullah Ozkaya  2 , Doukas Dardabounis  2 , Tulin Aras Ogreden  3 , Aristeidis Konstantinidis  2 , Konstantinos Kyratzoglou  2 , Ahmet Taylan Yazici  1
Affiliations

Focal laser photocoagulation in non-center involved diabetic macular edema

Irfan Perente et al. Med Hypothesis Discov Innov Ophthalmol. 2014 Spring.

Abstract

This study was performed to evaluate the functional and anatomic outcomes of focal macular laser photocoagulation in eyes with non-center involved macular edema (non-CI ME). Forty-nine eyes of 43 patients with non-CI ME were included. Focal macular laser photocoagulation was conducted on twenty-nine eyes of 25 patients, while 20 eyes of 18 patients with non-CI ME were followed without treatment and served as the control group. Data relating to best corrected visual acuity (BCVA; Early Treatment Diabetic Retinopathy Study) and central subfield thickness (CST), inner zone thickness (IZT), outer zone thickness (OZT), and total macular volume (TMV) as determined by optical coherence tomography (OCT) were collected and compared between the groups. At 12 months, VA decreased by a mean of 0.4 letters in the treatment group and 3.3 letters in the control group (p=0.03). Gain in VA ≥5 letters was noted in 6 (21%) of the eyes in the treatment group versus 1 (5%) eye in the control group (p=0.12). At 12 months, average IZT decreased by 22.6 microns in the treatment group and increased by 10.9 microns in the control group (p<0.001). The treatment group revealed significant reduction in CST, average OZT, and TMV as compared to the control group at 12 months (all p<0.05).Generally, focal laser photocoagulation may have more favourable visual outcomes in this specific group of diabetic patients than does observation. In addition, focal laser treatment provided better outcomes with improvement in OCT parameters as compared to the control group.

Keywords: Diabetic Macular Edema; Focal Macular Laser Photocoagulation; Laser Photocoagulation; Visual Acuity.

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Figures

Figure 1
Figure 1
Top: Angiographic leakage prior to laser treatment. Bottom: Decrease of the angiographic leakage following laser treatment.
Figure 2
Figure 2
Mean change in visual acuity letter score at follow-up visits in the two groups.
Figure 3
Figure 3
Mean change in average inner zone thickness at follow-up visits in the two groups.
Figure 4
Figure 4
Mean change in central subfield thickness at follow-up visits in the two groups.
Figure 5
Figure 5
Mean change in average outer zone thickness at follow-up visits in the two groups.
Figure 6
Figure 6
Mean change in total macular volume at follow-up visits in the two groups
See this image and copyright information in PMC

References

    1. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy IV Diabetic macular edema. Ophthalmology. 1984 Dec;91(12):1464–74. PMID: 6521986. - PubMed
    1. Photocoagulation for diabetic macular edema Early Treatment Diabetic Retinopathy Study Report Number 1. Early Treatment Diabetic Retinopathy Study Research Group. Arch Ophthalmol. 1985 Dec;103(12):1796–806. PMID: 2866759. - PubMed
    1. Browning DJ, Glassman AR, Aiello LP, Beck RW, Brown DM, Fong DS, Bressler NM, Danis RP, Kinyoun JL, Nguyen QD, Bhavsar AR, Gottlieb J, Pieramici DJ, Rauser ME, Apte RS, Lim JI, Miskala PH Diabetic Retinopathy Clinical Research Network, authors. Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema. Ophthalmology. 2007 Mar;114(3):525–36. PMID: 17123615. - PMC - PubMed
    1. Bandello F, Cunha-Vaz J, Chong NV, Lang GE, Massin P, Mitchell P, Porta M, Prünte C, Schlingemann R, Schmidt-Erfurth U. New approaches for the treatment of diabetic macular oedema: recommendations by an expert panel. Eye (Lond) 2012 Apr;26(4):485–93. PMID: 22241014. - PMC - PubMed
    1. Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 2. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1987 Jul;94(7):761–74. PMID: 3658348. - PubMed

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