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. 1989 Dec 7;342(6250):643-8.
doi: 10.1038/342643a0.

Cloning by functional expression of a member of the glutamate receptor family

M Hollmann  1 , A O'Shea-Greenfield, S W Rogers, S Heinemann
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Cloning by functional expression of a member of the glutamate receptor family

M Hollmann et al. Nature. .

Abstract

We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.

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