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. 2014 May;56(5):465-71.
doi: 10.1097/JOM.0000000000000142.

Urinary polycyclic aromatic hydrocarbon (OH-PAH) metabolite concentrations and the effect of GST polymorphisms among US Air Force personnel exposed to jet fuel

Ema G Rodrigues  1 , Kristen Smith, Alexis L Maule, Andreas Sjodin, Zheng Li, Lovisa Romanoff, Karl Kelsey, Susan Proctor, Michael D McClean
Affiliations

Urinary polycyclic aromatic hydrocarbon (OH-PAH) metabolite concentrations and the effect of GST polymorphisms among US Air Force personnel exposed to jet fuel

Ema G Rodrigues et al. J Occup Environ Med. 2014 May.

Abstract

Objective: To evaluate the association between inhalation exposure to jet propulsion fuel 8 (JP-8) and urinary metabolites among US Air Force (USAF) personnel, and investigate the role of glutathione S-transferase polymorphisms.

Methods: Personal air samples were collected from 37 full-time USAF personnel during 4 consecutive workdays and analyzed for JP-8 constituents and total hydrocarbons. Pre- and postshift urine samples were collected each day and analyzed for polycyclic aromatic hydrocarbon urinary metabolites.

Results: Work shift exposure to total hydrocarbons was significantly associated with postshift urinary 1-naphthol (β = 0.17; P = <0.0001), 2-naphthol (β = 0.09; P = 0.005), and 2-hydroxyfluorene concentrations (β = 0.08; P = 0.006), and a significant gene-environment interaction was observed with glutathione S-transferase mu-1.

Conclusions: USAF personnel experience inhalation exposure to JP-8, which is associated with absorption of JP-8 constituents while performing typical job-related tasks, and in our data the glutathione S-transferase mu-1 polymorphism was associated with differential metabolism of naphthalene.

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Conflict of interest statement

Authors Rodrigues, Smith, Maule, Sjodin, Li, Romanoff, Kelsey, Proctor, and McClean have no relationships/conditions/circumstances that present potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Postshift urinary metabolite concentrations among nonsmokers. **P = 0.0001; *P = 0.02.
FIGURE 2
FIGURE 2
Postshift urinary metabolite concentrations among smokers. *P = 0.02.
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References

    1. Agosta A. Development of a Chemical Surrogate for JP-8 Aviation Fuel Using a Pressurized Flow Reactor. Philadelphia, PA: Drexel University; 2002.
    1. Ritchie G, Still K, Rossi J, 3rd, Bekkedal M, Bobb A, Arfsten D. Biological and health effects of exposure to kerosene-based jet fuels and performance additives. J Toxicol Environ Health B Crit Rev. 2003;6:357–451. - PubMed
    1. Merchant-Borna K, Rodrigues EG, Smith KW, Proctor SP, McClean MD. Characterization of inhalation exposure to jet fuel among U.S. Air Force personnel. Ann Occup Hyg. 2012;56:736–745. - PubMed
    1. Pleil JD, Smith LB, Zelnick SD. Personal exposure to JP-8 jet fuel vapors and exhaust at air force bases. Environ Health Perspect. 2000;108:183–192. - PMC - PubMed
    1. Smith KW, Proctor SP, Ozonoff A, McClean MD. Inhalation exposure to jet fuel (JP8) among U.S. Air Force personnel. J Occup Environ Hyg. 2010;7:563–572. - PubMed

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