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. 2014 May;56(5):465-71.
doi: 10.1097/JOM.0000000000000142.

Urinary polycyclic aromatic hydrocarbon (OH-PAH) metabolite concentrations and the effect of GST polymorphisms among US Air Force personnel exposed to jet fuel

Ema G Rodrigues  1 , Kristen Smith, Alexis L Maule, Andreas Sjodin, Zheng Li, Lovisa Romanoff, Karl Kelsey, Susan Proctor, Michael D McClean
Affiliations

Urinary polycyclic aromatic hydrocarbon (OH-PAH) metabolite concentrations and the effect of GST polymorphisms among US Air Force personnel exposed to jet fuel

Ema G Rodrigues et al. J Occup Environ Med. 2014 May.

Abstract

Objective: To evaluate the association between inhalation exposure to jet propulsion fuel 8 (JP-8) and urinary metabolites among US Air Force (USAF) personnel, and investigate the role of glutathione S-transferase polymorphisms.

Methods: Personal air samples were collected from 37 full-time USAF personnel during 4 consecutive workdays and analyzed for JP-8 constituents and total hydrocarbons. Pre- and postshift urine samples were collected each day and analyzed for polycyclic aromatic hydrocarbon urinary metabolites.

Results: Work shift exposure to total hydrocarbons was significantly associated with postshift urinary 1-naphthol (β = 0.17; P = <0.0001), 2-naphthol (β = 0.09; P = 0.005), and 2-hydroxyfluorene concentrations (β = 0.08; P = 0.006), and a significant gene-environment interaction was observed with glutathione S-transferase mu-1.

Conclusions: USAF personnel experience inhalation exposure to JP-8, which is associated with absorption of JP-8 constituents while performing typical job-related tasks, and in our data the glutathione S-transferase mu-1 polymorphism was associated with differential metabolism of naphthalene.

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Conflict of interest statement

Authors Rodrigues, Smith, Maule, Sjodin, Li, Romanoff, Kelsey, Proctor, and McClean have no relationships/conditions/circumstances that present potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Postshift urinary metabolite concentrations among nonsmokers. **P = 0.0001; *P = 0.02.
FIGURE 2
FIGURE 2
Postshift urinary metabolite concentrations among smokers. *P = 0.02.
See this image and copyright information in PMC

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