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Comment

. 2014 May 6;106(9):1837-8.

doi: 10.1016/j.bpj.2014.03.041.

Biophysical studies reveal new evidence for one-way revolution mechanism of bacteriophage ϕ29 DNA packaging motor

Affiliations

Affiliation

¹ Nanobiotechnology Center, Markey Cancer Center, and College of Pharmacy, University of Kentucky, Lexington, Kentucky. Electronic address: peixuan.guo@uky.edu.

PMID: 24806913
PMCID: PMC4017282
DOI: 10.1016/j.bpj.2014.03.041

Comment

Biophysical studies reveal new evidence for one-way revolution mechanism of bacteriophage ϕ29 DNA packaging motor

Peixuan Guo. Biophys J. 2014.

. 2014 May 6;106(9):1837-8.

doi: 10.1016/j.bpj.2014.03.041.

Author

Affiliation

¹ Nanobiotechnology Center, Markey Cancer Center, and College of Pharmacy, University of Kentucky, Lexington, Kentucky. Electronic address: peixuan.guo@uky.edu.

PMID: 24806913
PMCID: PMC4017282
DOI: 10.1016/j.bpj.2014.03.041

No abstract available

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Figures

Figure 1
Illustration of the revolution mechanism without rotation. (A) Cartoon showing that rotation is like the Earth rotating around its own axis, and revolution motion is analogous to the Earth revolving around the Sun. (B) Diagram of dsDNA one-way revolution inside the 12 subunits of the connector channel wall (5). The loops (arrows on each subunit) within the channel serve as one-way valves that allow the dsDNA to advance into the procapsid, but do not allow movement in the opposite direction (8). To see this figure in color, go online.

See this image and copyright information in PMC

Comment on

Elastic properties and heterogeneous stiffness of the phi29 motor connector channel.
Kumar R, Grubmüller H. Kumar R, et al. Biophys J. 2014 Mar 18;106(6):1338-48. doi: 10.1016/j.bpj.2014.01.028. Biophys J. 2014. PMID: 24655509 Free PMC article.

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References

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1. Crozat E., Grainge I. FtsK DNA translocase: the fast motor that knows where it’s going. ChemBioChem. 2010;11:2232–2243. - PubMed
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1. Hugel T., Michaelis J., Bustamante C. Experimental test of connector rotation during DNA packaging into bacteriophage ϕ29 capsids. PLoS Biol. 2007;5:e59. - PMC - PubMed
1. Schwartz C., De Donatis G.M., Guo P. Revolution rather than rotation of AAA+ hexameric ϕ29 nanomotor for viral dsDNA packaging without coiling. Virology. 2013;443:28–39. - PMC - PubMed

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