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Comment
. 2014 May 6;22(5):664-6.
doi: 10.1016/j.str.2014.04.008.

Membrane interaction and functional plasticity of inositol polyphosphate 5-phosphatases

Werner Braun  1 , Catherine H Schein  2
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Membrane interaction and functional plasticity of inositol polyphosphate 5-phosphatases

Werner Braun et al. Structure. .
Free article

Abstract

In this issue of Structure, Trésaugues and colleagues determined the interaction of membrane-bound phosphoinositides with three clinically significant human inositol polyphosphate 5-phosphatases (I5Ps). A comparison to the structures determined with soluble substrates revealed differences in the binding mode and suggested how the I5Ps and apurinic endonuclease (APE1) activities evolved from the same metal-binding active center.

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