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. 1989 Dec 15;165(2):802-9.
doi: 10.1016/s0006-291x(89)80037-3.

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

M Palacios  1 , R G Knowles, R M Palmer, S Moncada
Affiliations

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

M Palacios et al. Biochem Biophys Res Commun. .

Abstract

The formation of nitric oxide (NO) by an L-arginine:NO synthase and its stimulation of the soluble guanylate cyclase was studied in rat whole adrenal and bovine cortex and medulla cytosol. In the presence of L-arginine, the stimulation of soluble guanylate cyclase was accompanied by the formation of citrulline and NO2-, formed from NO. The NO synthase was NADPH- and Ca(2+)-dependent and was inhibited by several L-arginine analogues. These results indicate that rat and bovine adrenal cytosol contains an L-arginine:NO synthase.

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