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. 2014 Mar 11:2014:745245.
doi: 10.1155/2014/745245. eCollection 2014.

Prevalence of deletional alpha thalassemia and sickle gene in a tribal dominated malaria endemic area of eastern India

Prasanta Purohit  1 , Snehadhini Dehury  1 , Siris Patel  2 , Dilip Kumar Patel  3
Affiliations

Prevalence of deletional alpha thalassemia and sickle gene in a tribal dominated malaria endemic area of eastern India

Prasanta Purohit et al. ISRN Hematol. .

Abstract

Inherited hemoglobin disorders like alpha thalassemia and sickle gene are common in the Indian subcontinent. These disorders in the heterozygous state act as malaria resistance genes and influence the susceptibility to Plasmodium falciparum malaria. There is inadequate knowledge about the epidemiology of these malaria resistance genes in the tribal dominated malaria endemic region of the state of Odisha in eastern India. A cross sectional prevalence study was undertaken in 594 subjects in five tribal populations in this region, namely, Sahara (42.4%), Kutia Kandha (30.0%), Kuda (15.8%), Gond (9.8%), and Oraon (2.0%). Sickling test, Hb electrophoresis, HPLC, and molecular studies were undertaken to diagnose the prevalence of sickle allele, β -thalassemia allele, and deletional alpha thalassemia. Sickle and β thalassemia alleles were found in 13.1% and 3.4% of subjects, respectively. Sickle allele was found both in heterozygous (10.1%) and homozygous state (3.03%). The prevalence of alpha thalassemia was 50.84% with an allelic frequency of 0.37. Both α (-3.7) and α (-4.2) alpha thalassemia were detected with an allele frequency of 0.33 and 0.04, respectively. The high prevalence of alpha thalassemia and sickle gene in this population is probably due to selection pressure of endemic malaria in this part of India.

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Figures

Figure 1
Figure 1
Prevalence of deletional alpha thalassemia alleles in the study subjects (n = 594).
Figure 2
Figure 2
Prevalence of sickle allele and β thalassemia allele in the study subjects (n = 594).
Figure 3
Figure 3
Prevalence of alpha thalassemia allele, sickle allele, and β thalassemia allele in five tribal communities in study subjects.
See this image and copyright information in PMC

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