Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:956901.
doi: 10.1155/2014/956901. Epub 2014 Apr 6.

High HPV infection prevalence in men from infertile couples and lack of relationship between seminal HPV infection and sperm quality

Barbara Golob  1 , Mario Poljak  2 , Ivan Verdenik  1 , Mojca Kolbezen Simoniti  1 , Eda Vrtačnik Bokal  1 , Branko Zorn  1
Affiliations

High HPV infection prevalence in men from infertile couples and lack of relationship between seminal HPV infection and sperm quality

Barbara Golob et al. Biomed Res Int. 2014.

Abstract

Human papillomaviruses (HPV) are the most frequently sexually transmitted viruses and etiological agents of several human cancers. Controversial results of the role of HPV in infertile population on sperm parameters have been published. The aim of this study was to estimate the type-specific prevalence of HPV DNA infection of the external genitalia and semen in 340 Slovenian men from infertile couples and to establish the relationship between seminal HPV DNA infection and abnormal sperm parameters. Self-taken swabs of the entire penile surface and semen samples were collected, and HPV detection and genotyping were performed. HPV DNA was detected in 37.12% of external genitalia and in 13.61% of semen samples with high HPV type concordance of both sampling sites. The most prevalent HPV types in the male external genitalia were HPV-CP6108 and HPV-84. The most prevalent HPV types in semen were HPV-53 and HPV-CP6108. The prevalence of HPV infection between normozoospermic men and men with abnormal sperm parameters did not differ significantly. Sperm quality did not differ significantly between men with seminal HPV infection and uninfected men. In conclusion, the men from infertile couples are equally susceptible to HPV infection regardless of their fertile potential; seminal HPV infection does not impair sperm quality.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Type-specific prevalence of HPV infection of penile surface in men from infertile couples (n = 299).
Figure 2
Figure 2
Type-specific prevalence of HPV infection of semen in men from infertile couples (n = 316).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Dunne EF, Nielson CM, Stone KM, Markowitz LE, Giuliano AR. Prevalence of HPV infection among men: a systematic review of the literature. Journal of Infectious Diseases. 2006;194(8):1044–1057. - PubMed
    1. Saccardi C, Gizzo S, Noventa M, et al. High-risk human papillomavirus DNA test: could it be useful in low-grade cervical lesion triage? Five-year follow-up. Reproductive Sciences. 2014;21(2):198–203. - PubMed
    1. 2014, http://pave.niaid.nih.gov.
    1. Rintala MAM, Pollanen PP, Nikkanen VP, Grenman SE, Syrjänen SM. Human papillomavirus DNA is found in the vas deferens. Journal of Infectious Diseases. 2002;185(11):1664–1667. - PubMed
    1. Martorell M, Gil-Salom M, Pérez-Vallés A, Garcia JA, Rausell N, Senpere A. Presence of human papillomavirus DNA in testicular biopsies from nonobstructive azoospermic men. Archives of Pathology & Laboratory Medicine. 2005;129(9):1132–1136. - PubMed

LinkOut - more resources