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Comparative Study
. 1989 Sep-Oct;52(5):31-3.

[The effect of antihistamine preparations on the contraction of the isolated guinea pig ureter]

[Article in Russian]
M E Kaminka, M L Zhirnikova
  • PMID: 2480912
Comparative Study

[The effect of antihistamine preparations on the contraction of the isolated guinea pig ureter]

[Article in Russian]
M E Kaminka et al. Farmakol Toksikol. 1989 Sep-Oct.

Abstract

The effect of antihistaminics on contractions of the isolated guinea pig ureter was studied. The ureter contractions induced by histamine were prevented by H1-blockers: pipolphen (promethazine), dimedrol (diphenhydramine), phencarol (quifenadine), suprastin (chloropyramine), cyproheptadine and H2-blockers: cimetidine, ranitidine. Electric stimulation-induced contractions were prevented by suprastin. Phencarol, tavegil, cimetidine, ranitidine didn't act on the contractions. The electrically induced contractions were potentiated by pipolphen, dimedrol, cyproheptadine.

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