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. 2014 Jul;32(6):291-8.
doi: 10.3109/07357907.2014.911880. Epub 2014 May 9.

Tumor acquisition for biomarker research in lung cancer

Marvaretta Stevenson  1 , Jared Christensen, Debra Shoemaker, Traci Foster, William T Barry, Betty C Tong, Momen Wahidi, Scott Shofer, Michael Datto, Geoffrey Ginsburg, Jeffrey Crawford, Thomas D'Amico, Neal Ready
Affiliations

Tumor acquisition for biomarker research in lung cancer

Marvaretta Stevenson et al. Cancer Invest. 2014 Jul.

Abstract

The biopsy collection data from two lung cancer trials that required fresh tumor samples be obtained for microarray analysis were reviewed. In the trial for advanced disease, microarray data were obtained on 50 patient samples, giving an overall success rate of 60.2%. The majority of the specimens were obtained through CT-guided lung biopsies (N = 30). In the trial for early-stage patients, 28 tissue specimens were collected from excess tumor after surgical resection with a success rate of 85.7%. This tissue procurement program documents the feasibility in obtaining fresh tumor specimens prospectively that could be used for molecular testing.

Keywords: Bioinformatics; Gene profiling; Lung cancer.

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Figures

Figure 1
Figure 1
Specimen collection and processing flow chart.
Figure 2
Figure 2
REMARK diagram for ClinicalTrials.gov Identifier NCT00509366.
Figure 3
Figure 3
REMARK diagram for ClinicalTrials.gov Identifier NCT00545948.
See this image and copyright information in PMC

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