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. 2014 Nov;61(11):2080-2.
doi: 10.1002/pbc.25090. Epub 2014 May 9.

Sustained complete molecular remission after imatinib discontinuation in children with chronic myeloid leukemia

Olga Moser  1 , Manuela Krumbholz, Christian Thiede, Josephine T Tauer, Indra Janz, Melchior Lauten, Dagmar Dilloo, Markus Metzler, Meinolf Suttorp
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Sustained complete molecular remission after imatinib discontinuation in children with chronic myeloid leukemia

Olga Moser et al. Pediatr Blood Cancer. 2014 Nov.

Abstract

Approximately 40% of adults with chronic myeloid leukemia (CML) in prolonged complete molecular response (CMR) remain in CMR after imatinib discontinuation. Corresponding information in children is lacking. Two children with CML in CMR for 48 and 19 months after imatinib discontinuation showed low-level fluctuating disease at RNA transcript and genomic DNA levels. Both patients were low risk according to adult criteria. Since adults with molecular relapse responded to re-introduction of imatinib, we postulated that treatment discontinuation in low risk children might be justified within clinical trials with close monitoring. This may help to minimize exposure to imatinib and its potential side effects.

Keywords: CML; childhood; imatinib.

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