Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014;13(11):1661-2.
doi: 10.4161/cc.29151. Epub 2014 May 8.

p53, DNA damage, and NAD+ homeostasis

Neil T Pfister  1 , Kathryn E Yoh  1 , Carol Prives  1
Affiliations
Comment

p53, DNA damage, and NAD+ homeostasis

Neil T Pfister et al. Cell Cycle. 2014.
No abstract available

PubMed Disclaimer

Figures

None
Figure 1. Damage-stabilized p53 transcriptionally activates NMNAT-2, leading to increased levels of NAD+. Increased availability of NAD+ may then increase SIRT1 and PARP1 activity, which can both directly and indirectly affect p53 response to cell stress. A putative negative feedback mechanism may exist whereby SIRT1 may downregulate p53 transcription of NMNAT-2 by limiting p53 nuclear translocation.
See this image and copyright information in PMC

Comment on

References

    1. Vousden KH, et al. Nat Rev Cancer. 2009;9:691–700. doi: 10.1038/nrc2715. - DOI - PubMed
    1. Yi J, et al. Biochim Biophys Acta. 2010;1804:1684–9. doi: 10.1016/j.bbapap.2010.05.002. - DOI - PMC - PubMed
    1. Elkholi R, et al. Bioessays. 2014;36:46–51. doi: 10.1002/bies.201300117. - DOI - PMC - PubMed
    1. Pan LZ, et al. Cell Cycle. 2014;13:1041–8. doi: 10.4161/cc.28128. - DOI - PMC - PubMed
    1. Montero J, et al. Cell Death Differ. 2013;20:1465–74. doi: 10.1038/cdd.2013.52. - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources