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. 1989 Dec;86(24):10171-5.
doi: 10.1073/pnas.86.24.10171.

Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes

M Price  1 , S C Lee, C Deutsch
Affiliations

Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes

M Price et al. Proc Natl Acad Sci U S A. 1989 Dec.

Abstract

We demonstrate that blockade of the lymphocyte voltage-gated K+ channel by charybdotoxin (CTX) inhibits lymphocyte mitogenesis. Charybdotoxin blocks conductance with a Ki of 0.3 nM and inhibits mitogen- and antigen-stimulated proliferation with a Ki of 0.5 nM. As opposed to the other blockers of the lymphocyte K+ channel, the inhibition of mitogenesis by CTX can be overcome selectively by exogenous recombinant interleukin 2 (IL-2); endogenous levels of IL-2 in the culture supernatants of stimulated cells are decreased by the presence of CTX. Our results suggest that the voltage-gated K+ channel is either directly or indirectly involved in IL-2 synthesis and/or secretion.

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References

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